Yamamoto Research Glucovit is a dietary supplement based on plant extracts, berberis extract contributes to the regular function of the cardiovascular system, while bitter melon and gymnema support carbohydrate metabolism. Gymnema also plays a role in controlling the sense of hunger and supporting lipid metabolism. Bitter melon contributes to the physiological arterial pressure and berberis, momordica and cinnamon help maintain regular intestinal transit. Keeping blood glucose under control is essential for health, since too high levels lead to weight gain over time, to a specific form of damage caused by the reaction of glucose with proteins. i.e. glycation, and to disorders related to insulin resistance that can open the door to serious diseases such as arteriosclerosis and cardiovascular incidents. When proper nutrition and healthy physical activity do not suffice, nature may still also come to your aid with the active phytoextract elements contained in Glucovit. This food supplement uses the synergy of effective natural hypoglycemic agents such as Berberine, Bitter Melon, Gymnema Sylvestre and Cinnamon. Berberine is an alkaloid extracted from plants such as barberry (Berberis Vulgaris) that has been used for some time in Chinese and Ayurvedic medicine. It has interesting beneficial properties relating to blood glucose reduction and its best use by the cell that have also been demonstrated recently in modern scientific literature. In the last ten years, research has shown a growing interest in its extraordinary effects on metabolic diseases (type 2 diabetes, pre-diabetic states) and cardiovascular diseases that are constantly increasing in Western societies, and its fundamental role in the activation of a key metabolic enzyme, namely AMPK. Among its many beneficial properties, Berberine activates AMPK that acts on different levels: increasing the production of GLUT4 (a glucose transporter that is only found in muscle and fat cells) and improving sensitivity to insulin, facilitating the intra-cellular transport of glucose, allowing the body to make better use of both glucose and insulin and, thereby, lowering glucose and glycated haemoglobin (HbA1c) levels in the blood. It also stimulates the metabolism of fatty acids in the mitochondria and reduces the levels of circulating lipids, triglycerides and LDL cholesterol, in the blood. Glucovit also contains bitter Melon, a fruit that contains a mixture of saponins, and is thus considered to be one of the most effective in combating type 2 diabetes thanks to its beneficial hypoglycemic and insulin-like properties. Extensive studies have confirmed its effectiveness in counteracting glucose uptake and its hypoglycemic action, and shown that Gymnema Sylvestre is able to reduce plasma glucose levels by stimulating pancreatic insulin secretion (action at the pancreas beta cell level). Gimnemic acid, with the structure very similar to that of glucose, exerts its action in the intestine where the glucose receptor is reversibly blocked (the block, established one hour after administration, remains active for 5 or 6 hours), significantly reducing the absorption of carbohydrates. Several scientific studies have shown that cinnamon has a potent hypoglycemic action and creates greater sensitivity to insulin, allowing glucose to enter the peripheral tissues of the cells more efficiently. In addition, studies show how cinnamon exerts this effect by helping to slow gastric emptying and, consequently, the entry of sugars into the circulation and how its antioxidants are able to block the digestive enzymes of the intestinal catabolism of carbohydrates, reducing their entry into the circulation. svolge inoltre n importantissimo ruolo di idratante della cellula muscolare.