What is Doctor’s Best Doctor’s Best SAM-e? Doctor’s Best SAM-e is proven to enhance mood and promote cognitive health. It is essential for the healthy metabolism of the major brain transmitters' dopamine, serotonin and norepinephrine. In addition, SAM-e promotes joint comfort and mobility and supports liver health and detoxification. SAM-e effectiveness has been published in 18 controlled human trials published over 40 years. Doctor’s Best SAM-e uses pharmaceutical grade materials. SAM-e is derived from the amino acid methionine and is one of the most important methyl donors in the central nervous system. SAM-e optimized for potency, stability, and to survive the stomach acid and reach the intestine (where it is absorbed). Effectiveness of SAM-e has been backed by at least 18 controlled human trials published over almost four decades. How does it work? S-Adenosyl Methionine (SAM-e) is produced by the body from ATP and the amino acid methionine which is one of the most important methyl donors in the central nervous system. Methylation (donation of methyl groups) is an essential process in ensuring the proper function of a number of organ systems. SAM-e is involved in numerous biochemical reactions in tissue including the liver, joints and brain. SAM-e is also required for the biosynthesis of critical neurotransmitters and hormones. Why should I take Doctor’s Best SAM-e? SAM-e is a biological compound found in every living cell of the human body, vital to their function, stability and activity and involved in more than one hundred biochemical reactions and specific processes. SAM-e helps promote healthy mood. So if your body is not producing enough SAM-e, you might feel blue or have trouble sleeping. And according to the Center for Disease Control, an estimated 1 in 10 American adults say they are depressed. Supplementing with Doctor’s Best SAM-e can help and improve your quality of life.