What Does Methyl B-12 & Methyl Folate Do? Jarrow Formulas Methyl B-12, Methylfolate Plus Pyridoxal-5-Phosphate (P5P) Lozenge combines the active forms of these vitamins to support DNA and neurotransmitter synthesis and amino acid metabolism. Homocysteine is converted to methionine by methylfolate and B12, and to cysteine by P5P-dependent enzymes.