Yamamoto Nutrition Mega SAUZER is a citrulline, beta alanine and arginine alpha-ketoglutarate food supplement with taurine, branched chain amino acids (BCAA), vitamins C, B6 and B12 and plant extracts, with caffeine and other nutrition factors. The product is suitable for adult sportsmen who practice intense physical activity as a pre-workout. Branched chain amino acids are suitable for supplementation of sportsman s diet. Vitamins C, B6 and B12 contribute to the reduction of tiredness and fatigue and to normal energy-yielding metabolism, while vitamin B6 also contributes to the normal protein and glycogen metabolism. The release of the new version of Shura KHAN has projected pre-workout supplements without stimulants forward into a new generation, by using high quality raw materials (many of them patented) with proven effectiveness. That s why, on the enthusiastic wave of Shura KHAN, comes the new and redesigned Mega SAUZER. Reformulated and renewed, the historical king of the Yamamoto pre-workout line represents itself with the inclusion of elements that will exalt the already known qualities. It has three particular strengths, nitric oxide stimulation, ergogenic-adrenergic stimulation and the more recent addition, a nootropic substance to ensure an unprecedented lucid focus during training. Objective: the formulation of supplements that really work, and always better, thanks to the more real scientific research tailored to the needs of the athlete, and to the most qualitative certified raw materials. To promote maximum blood flow and therefore a better transport of oxygen and nutrients to the muscles, Citrulline malate is a great protagonist, with well-known characteristics that place it among the most effective nitric oxide stimulating elements, even with respect to arginine itself. In this regard, I always stress that after oral intake, arginine is subject to extensive pre-systemic and systemic elimination due to intestinal bacteria and hepatic and intestinal arginases that convert it into ornithine and urea. These factors significantly reduce the amount of arginine available for nitric oxide synthesis and for the other functions it is responsible for, limiting the efficacy of a specific oral supplement of arginine, so much appreciated in the past but still present in an excessive amount and often overestimated for the intended purposes. On the other hand, the amino acid Citrulline is not subjected to the presystemic and first pass elimination described above, and can be converted first into argininosuccinate, then into arginine, thus acting as a precursor of this