Medol is a food supplement indicated for women based on extracts of chasteberry, angelica, feverfew, magnesium and vitamin B6. The chasteberry, angelica and feverfew help to counteract the disorders of the menstrual cycle. Magnesium contributes to the reduction of tiredness and fatigue and to normal psychological function. Vitamin B6 contributes to the normal formation of red blood cells, the regulation of hormonal activity and the normal functioning of the nervous system. Many women suffer from annoying disorders, often even limiting ones, in the days preceding the menstrual cycle, the PMS, premenstrual syndrome. These disorders manifest themselves with complex symptomatology, in some cases with very acute and disabling forms even for a few days. PMS is felt about 7-10 days before the onset of menstruation, with pain and tension in the breast, frequent headache, irritability with marked mood drops, increased anxiety, greater tiredness, swelling of the abdomen and lower limbs, pimples, tendency to seek sweet and greasy food. All this complex of PMS symptoms has not been attributed to a univocal cause as it is thought that there are several factors that act synergistically. Hormonal changes during the menstrual cycle seem to be an important cause, but there may also be in place some neurotransmitters imbalances (see dopamine and serotonin) capable of influencing stress levels and mood swings, even causing a slight form of depression. Although hormones and neurotransmitters imbalances don t seem to cause the syndrome, they can surely emphasize it. Scientific data attribute to the magnesium deficiency the responsibility of symptoms such as headache, muscle cramps, and uterus pain due to an increase in hormones that regulate the balance of mineral salts in our body. In regard to hormonal imbalances, an increase in the level of estrogen and prolactin is also thought to be the basis of the increase of breast volume and water retention that causes weight gain and constipation. The fact is that many women in these particular days suffer from all (or part of) these psychophysical symptoms lead to more or less debilitating conditions. In this regard, nutraceuticals have been shown to have some interesting and effective weapons to prevent or alleviate, at least in part, these nuisances. The chasteberry (Vitex Agnus Castus L.) is also called the chaste tree or tree of chastity because, in the Middle Ages, it was used by monks