What Does Joint Builder Do? Glucosamine Sulfate is a stable, clinically studied form of glucosamine, which is essential for the proper formation of tendons, ligaments, synovial fluid, bones, skin, nails and blood vessels. MSM is a sulfur donor; sulfur is essential for the formation of chondroitin sulfates. Vitamin C and manganese are required for synthesis of collagen and cartilage. Adequate Vitamin D3 supports joint health.