HMB Muscle building and fat loss enhancing formula HMB (hydroxy-methyl-butyrate) is teh metabolite of the important branched-chain amino acid leucine that mediates its anabolic and anticatabolic effect. HMB has been shown clinically to increase muscle size, strength and improve fat burning in response to exercise. It’s best to use HMB in conjunction with a strenuouns training program or a strict diet regimen where catabolism and overtraining may easily occur.