Longvida Optimized Curcumin Crosses Blood-Brain Barrier Free Form Curcumin with Superior Bioavailability Curcumin is a powerful free radical neutralizer that is known to support balanced immune function, but is also known to have poor bioavailability. NOW CurcuBrain features Longvida Optimized Curcumin, which in studies exhibits up to 65 times the bioavailability of free curcuminoids compared with generic curcumin. Longvida is absorbed by the GI tract and delivered to the rest of the body as free curcumin, the active form in the body. Longvida is shown to penetrate the blood-brain barrier for the support of healthy neuronal tissues.