Joint Mobility and Comfort Tissue Elasticity Chondroitin Sulfate is a glycosaminoglycan (GAG) naturally present in many body tissues, and is an especially important component of joint cartilage and synovial tissue. Chondroitin promotes water retention within the joint, giving it resiliency by acting as a lubricant and a means to absorb shock. This nutrient thus helps to support the maintenance of healthy, flexible joint tissue and promotes proper joint mobility and comfort.