What is Doctor’s Best Carnosine? Doctor’s Best Carnosine offers fundamental support for healthy brain function, helps protect cells and enzymes against damage and helps promote cell-level stress tolerance. Carnosine is a naturally occurring dipeptide (Beta-Alanine-L-Histidine), concentrated in the brain and muscles, and has a uniquely broad range of protective properties. It helps neutralize free radicals of oxygen and nitrogen, and can sequester or chelate potentially toxic metal atoms. How does it work? Carnosine protects cells in several ways, it is a key buffer against lactic acid produced during metabolism, helping to ensure a healthy acid-alkaline balance within the cell environment. It has also been shown to sequester or chelate potentially toxic metal atoms. Carnosine is known to have the ability to neutralize “free radicals” and thereby protect cells from reactive free radicals. It also helps protect against protein damage by methylglyoxal, a byproduct of energy generation. Carnosine has also been shown to inhibit the production of compounds called AGEs, or “advanced glycation end-products”. AGEs are compounds that are formed when proteins become oxidized by sugars, hence “glycated”. The presence and accumulation of AGEs is known to impact protein structure and function, both within and outside the cells. AGEs may contribute to accelerated aging.