What is Doctor’s Best Hesperidin Methyl Chalcone? Doctor’s Best Hesperidin Methyl Chalcone is a flavonoid derived from citrus fruits that helps protect heart & blood vessels from oxidation, supports vascular health and helps improve capillary strength. It provides hesperidin methyl chalcone, the methylated derivative of hesperidin, which may be the more beneficial form. How does it work? Hesperidin is a powerful neutralizer of free radicals. In cell culture experiments, hesperidin provided strong protection against agents that could cause cell damage via the production of superoxide and hydroxyl free radicals from oxygen. The potent antioxidant activity of hesperidin, and/or metabolic products derived from it, is one likely basis for its structural support of the capillaries and other small blood vessels.